Caffeic acid
Caffeic acid has been shown to inhibit carcinogenesis, although other experiments show possiblecarcinogenic effects. It is also known as an antioxidant in vitro and also in vivo.
Features
Synonyms: 3,4-Dihydroxycinnamic Acid
CAS.NO: 331-39-5
Molecular Formula:C9H8O4
Molecular Weight: 180.16
Test Method And Purity:HPLC ≥98%
Basic Information
Product Name:Caffeic Acid
Synonyms: 3,4-Dihydroxycinnamic Acid
CAS.NO: 331-39-5
Molecular Formula:C9H8O4
Molecular Weight: 180.16
Test Method And Purity:HPLC ≥98%
Function
Immunomodulatory and Anti-Inflammatory Actions
Beyond its antioxidant properties, caffeic acid has noteworthy immunomodulatory and anti-inflammatory activities. One remarkable study highlighted that caffeic acid can reduce the production of aflatoxins by more than 95%, outperforming other antioxidants. This finding indicates that caffeic acid can effectively mitigate oxidative stress that would otherwise exacerbate aflatoxin production by the fungus Aspergillus flavus, suggesting potential natural antifungal applications by supplementing plants with antioxidants.
Therapeutic Potential
Further research into caffeic acid phenethyl ester (CAPE), a derivative of caffeic acid, revealed its capability to suppress acute immune and inflammatory responses. This positions CAPE as a promising candidate for therapeutic applications aimed at reducing inflammation and enhancing overall immune function.
Application
Mechanism of Action
The tumor-suppressing effects of CA and CAPE are thought to be mediated by their ability to selectively inhibit MMP-9 enzyme activity and down-regulate its transcription. This dual mechanism involves the inhibition of NF-κB signaling pathways and the catalytic activity of MMP-9, which are crucial for tumor growth and metastasis.
Epigenetic Modulation
In addition to their anti-metastatic properties, Caffeic Acid and chlorogenic acid, which is found in coffee beans, have been shown to reduce DNA methylation in vitro in two lines of human cancer cells. DNA methylation is a key epigenetic modification that plays a role in tumor growth and cellular regulation, suggesting that these compounds could contribute to cancer prevention and treatment by altering epigenetic expression patterns.
Therapeutic Implications
The findings surrounding Caffeic Acid and CAPE underline their therapeutic potential in combating cancer, specifically by targeting and inhibiting critical enzymes and genetic pathways involved in tumor growth and metastasis. This research opens up new avenues for the development of anti-cancer drugs derived from natural compounds.
Specifications Sheet
| Certificate of Analysis | ||
| Item | Specification | Result |
| Assay | 99% | 99.68% |
| Appearance | Light Yellow Powder | conforms |
| Odor | Characteristic | conforms |
| Taste | Characteristic | conforms |
| Particle Size | NLT 100% Through 80 mesh | conforms |
| Loss on Drying | <2.0% | 0.47% |
| Heavy metals | ||
| Total Heavy Metals | ≤10ppm | conforms |
| Arsenic | ≤3ppm | conforms |
| Lead | ≤3ppm | conforms |
| Microbiological Tests | ||
| Total Plate Count | ≤1000cfu/g | conforms |
| Total Yeast & Mold | ≤100cfu/g | conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
Shipping & Storage
Delivery:Sea/Air Shipping & International Express
Shipping Time: 2-3 working days after payment
Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)
15-25kg/Drum, size: 38cm (Diameter)*50cm (Height)
Storage: Kept away from strong light and heat.
Shelf Life: 24 months
Quality&Certifications
