Camptothecin
Camptothecin is a quinoline-based alkaloid found in the barks of the chinese camptotheca tree and the Asian nothapodytes tree.
Features
CAS No. 7689-03-4
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf
Basic Information
Product name: Camptothecin
CAS No. 7689-03-4
Molecular formula: C20H16N2O4
Molecular weight: 348.36
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf
Grade: Pharmaceutical and food
Function
Mechanism of Action
Camptothecin and its derivatives uniquely inhibit DNA Topoisomerase I by stabilizing a covalent intermediate known as the cleavable complex, which ultimately leads to tumor cell death.
Clinical Efficacy
Clinically, camptothecin analogs are noted for their significant anti-tumor and anti-leukemia activities. Topoisomerase is an essential enzyme in DNA replication, responsible for unwinding and winding the supercoiled DNA in chromosomes. If chromosomal DNA cannot be unwound, DNA transcription and protein synthesis are halted, leading to cell death.
Limitations in Clinical Use
The clinical application of camptothecin is limited by serious side effects and poor water solubility.
Therapeutic Developments
Currently, several camptothecin analogs, both semi-synthetic and synthetic, have been developed for cancer treatment and have shown promising therapeutic effects in clinical settings.
Application
1.It is mainly used in pharmaceutical field;
2.It is mainly used in health product industry.
3.Medicine and health products and food additives.
Specifications Sheet
| Analysis | Specification | Results |
| Assay(Camptothecin ) | ≥98.0% | 98.43% |
| Physical & Chemical Control | ||
| Identification | Positive | Complies |
| Appearance | White Powder | Complies |
| Odor | Characteristic | Complies |
| Mesh Size | 80 mesh | Complies |
| Loss On Drying | ≤5.0% | 2.27% |
| Methanol | ≤5.0% | 0.024% |
| Ethanol | ≤5.0% | 0.150% |
| Residue on Ignition | ≤3.0% | 1.05% |
| Heavy Metal Testing | ||
| Heavy Metals | ＜20ppm | Complies |
| As | ＜2ppm | Complies |
| LEAD(Pb) | < 0.5PPM | 0.22 ppm |
| MERCURY(Hg) | Not dectect | Complies |
| CADMIUM | < 1 PPM | 0.25 ppm |
| COPPER | < 1 PPM | 0.32 ppm |
| ARSENIC | < 1 PPM | 0.11 ppm |
| Microbiological | ||
| Total Plate Count | <1000/gMax | Complies |
| Staphylococcus Aurenus | Not Detected | Negative |
| Pseudomonas | Not Detected | Negative |
| Yeast & Mold | <100/gMax | Complies |
| Salmonella | Negative | Negative |
| E. Coli | Negative | Negative |
Shipping & Storage
Delivery:Sea/Air Shipping & International Express
Shipping Time: 2-3 working days after payment
Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)
15-25kg/Drum, size: 38cm (Diameter)*50cm (Height)
Storage: Kept away from strong light and heat.
Shelf Life: 24 months
Quality&Certifications
