Camptothecin


Camptothecin-NutriHerb

Camptothecin

Camptothecin is a quinoline-based alkaloid found in the barks of the chinese camptotheca tree and the Asian nothapodytes tree.

Features

CAS No. 7689-03-4
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf

 

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    Basic Information

    Product name: Camptothecin
    CAS No. 7689-03-4
    Molecular formula: C20H16N2O4
    Molecular weight: 348.36
    Specification: 98%,99% Camptothecin
    Test method: HPLC
    Appearance: Light yellow crystal powder
    Source: Camptotheca Acuminata Decne's leaf
    Grade: Pharmaceutical and food

    Function

    Mechanism of Action

    Camptothecin and its derivatives uniquely inhibit DNA Topoisomerase I by stabilizing a covalent intermediate known as the cleavable complex, which ultimately leads to tumor cell death.

    Clinical Efficacy

    Clinically, camptothecin analogs are noted for their significant anti-tumor and anti-leukemia activities. Topoisomerase is an essential enzyme in DNA replication, responsible for unwinding and winding the supercoiled DNA in chromosomes. If chromosomal DNA cannot be unwound, DNA transcription and protein synthesis are halted, leading to cell death.

    Limitations in Clinical Use

    The clinical application of camptothecin is limited by serious side effects and poor water solubility.

    Therapeutic Developments

    Currently, several camptothecin analogs, both semi-synthetic and synthetic, have been developed for cancer treatment and have shown promising therapeutic effects in clinical settings.

    Application

    1.It is mainly used in pharmaceutical field;
    2.It is mainly used in health product industry.
    3.Medicine and health products and food additives.

    Specifications Sheet

    Analysis Specification Results
    Assay(Camptothecin ) ≥98.0% 98.43%
    Physical & Chemical Control
    Identification Positive Complies
    Appearance White Powder Complies
    Odor Characteristic Complies
    Mesh Size 80 mesh Complies
    Loss On Drying ≤5.0% 2.27%
    Methanol ≤5.0% 0.024%
    Ethanol ≤5.0% 0.150%
    Residue on Ignition ≤3.0% 1.05%
    Heavy Metal Testing
    Heavy Metals <20ppm Complies
    As <2ppm Complies
    LEAD(Pb) < 0.5PPM 0.22 ppm
    MERCURY(Hg) Not dectect Complies
    CADMIUM < 1 PPM 0.25 ppm
    COPPER < 1 PPM 0.32 ppm
    ARSENIC < 1 PPM 0.11 ppm
    Microbiological
    Total Plate Count <1000/gMax Complies
    Staphylococcus Aurenus Not Detected Negative
    Pseudomonas Not Detected Negative
    Yeast & Mold <100/gMax Complies
    Salmonella Negative Negative
    E. Coli Negative Negative

     

    Shipping & Storage

    Delivery:Sea/Air Shipping & International Express

    Shipping Time: 2-3 working days after payment

    Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)

    15-25kg/Drum, size: 38cm (Diameter)*50cm (Height)

    Storage: Kept away from strong light and heat.

    Shelf Life: 24 months

    Packaging-NutriHerb

    Quality&Certifications

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