What Is Ursolic Acid
Ursolic acid is a pentacyclic triterpene acid, used in cosmetics that is also capable of inhibiting various cancer cell types by inhibiting the STAT3 activation pathway, one of which includes human fibrosarcoma by reducing expression of matrix metalloproteinase-9 via glucocorticoid receptors. It may also decrease proliferation of cancer cells and induce apoptosis.[4] Ursolic acid has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation. Ursolic acid is present in many plants, including apples, basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, and prunes. Bearberry contain large quantities of ursolic acid and related compounds.
Ursolic acid can serve as a starting material for synthesis of more potent bioactive derivatives, such as antitumor agents. It has been found to reduce muscle atrophy and to stimulate muscle growth in mice. Ursolic acid has potential use as a cardioprotective compound.
Ursolic acid has medicinally action, both topically and internally. Ursolic acid is used in many cosmetic preparations for its anti-inflammatory, antitumor and antimicrobial properties.
Ursolic acid has antibacterial and antifungal activity. Tests have shown that Ursolic acid inhibits the growth of Candida albicans and Microsporium lenosum.
Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns.
Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth.
Ursolic Acid is found in apple peel first. With the value of usolic acid enhance, the better usolic acid have found in the bearberry.
Bearberries are three species of dwarf shrubs in the genus Arctostaphylos. Unlike the other species of Arctostaphylos, they are adapted to Arctic and Subarctic climates, and have a circumpolar distribution in northern North America, Asia and Europe, one with a small highly disjunctive population in Central America.
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